Neurocardiogenic syncope in children: Current concepts in diagnosis and management

被引：5

作者：

Martial M. Massin

机构：

[1] Division of Pediatric Cardiology, University of Liège, Reg. Hospital Centre La Citadelle, Liège

[2] Division of Pediatric Cardiology, CHR Citadelle, University of Liège, B-4000 Liège, Boulevard du 12 de Ligne

来源：

Pediatric Drugs | 2003年 / 5卷 / 5期

关键词：

Chronic Fatigue Syndrome; Disopyramide; Midodrine; Fludrocortisone; Orthostatic Intolerance;

D O I：

10.2165/00128072-200305050-00005

中图分类号：

学科分类号：

摘要：

A wide variety of pharmacologic agents are currently used for the prevention of recurrent neurocardiogenic syncope in children and adolescents. Significant advances in the understanding of this syncopal disorder have occurred in the past decade, and the list of medications recommended has changed, reflecting the evolving understanding of the pathophysiology and development of agents with enhanced efficacy and fewer adverse effects. Clinicians have few randomized controlled trials available to guide their decisions about treating neurocardiogenic syncope, and even fewer when it comes to medications targeting the pediatric population. At the present time, β-adrenergic receptor blockers, fludrocortisone, and also specific serotonin reuptake inhibitors and midodrine, appear to be favored treatment options. Ideally, specific therapy would be tailored to specific pathophysiologic mechanisms. Unfortunately, at present, specific treatments based on those abnormalities have not been identified.

引用

页码：327 / 334

页数：7

共 34 条

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