Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer’s disease cybrid cells

被引：0
作者：
Jin-Heon Jeong
Kyu Sun Yum
Jun Young Chang
Manho Kim
Jin-young Ahn
SangYun Kim
Paul A Lapchak
Moon-Ku Han
机构：
[1] Chungbuk National University,Department of Neurology, College of Medicine
[2] Chungbuk National University Hospital,Department of Neurology, College of Medicine
[3] Konyang University,Department of Neurology, College of Medicine
[4] Konyang University Hospital,Department of Neurology, College of Medicine
[5] Seoul National University,Department of Neurology
[6] Seoul National University Bundang Hospital,Departments of Neurology and Neurosurgery
[7] Seoul National University,undefined
[8] Seoul National University Hospital,undefined
[9] Seoul Medical Center,undefined
[10] Cedars-Sinai Medical Center,undefined
来源：
BMC Neurology | / 15卷
关键词：
Alzheimer’s disease; Cybrid cell; Statin; Hypoxia; HIF-1α; BACE;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells
    Zhang, Yong
    Jiang, Li
    Qin, Nianqun
    Cao, Mi
    Liang, Xiujuan
    Wang, Rensheng
    [J]. BIOCHEMISTRY AND CELL BIOLOGY, 2021, 99 (02) : 203 - 213
  • [32] Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1α
    Zhao, Wei
    Xia, Shi-Qi
    Zhuang, Jin-Peng
    Zhang, Zhi-Peng
    You, Chang-Cheng
    Yan, Jing-Long
    Xu, Gong-Ping
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2016, 420 (1-2) : 1 - 8
  • [33] HIF-1α forms regulatory loop with YAP to coordinate hypoxia-induced adriamycin resistance in acute myeloid leukemia cells
    Zhu, Bin
    Pan, Shaoying
    Liu, Juanjuan
    Wang, Suli
    Ni, Ying
    Xiao, Linlin
    Wei, Quhao
    Peng, You
    Ding, Zhiyong
    Zhao, Wenli
    [J]. CELL BIOLOGY INTERNATIONAL, 2020, 44 (02) : 456 - 466
  • [34] NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells
    Wang, Lifeng
    Liu, Na
    Yao, Libo
    Li, Fuyang
    Zhang, Jian
    Deng, Yanchun
    Liu, Junye
    Ji, Shaoping
    Yang, Angang
    Han, Hua
    Zhang, Yingqi
    Zhang, Jing
    Han, Wei
    Liu, Xinping
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2008, 21 (1-3) : 239 - 250
  • [35] MicroRNA-150 attenuates hypoxia-induced excessive proliferation and migration of pulmonary arterial smooth muscle cells through reducing HIF-1α expression
    Chen, Mantian
    Shen, Chengxing
    Zhang, Yi
    Shu, Hong
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2017, 93 : 861 - 868
  • [36] SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells
    Wang, Xiaowei
    Liang, Xiaoju
    Liang, Huan
    Wang, Bing
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (02) : 1819 - 1826
  • [37] HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells
    Tong, Ying
    Li, Qi-Gen
    Xing, Tian-Yu
    Zhang, Ming
    Zhang, Jian-Jun
    Xia, Qiang
    [J]. FEBS LETTERS, 2013, 587 (16) : 2530 - 2535
  • [38] Novel Pathway for Hypoxia-Induced Proliferation and Migration in Human Mesenchymal Stem Cells: Involvement of HIF-1α, FASN, and mTORC1
    Lee, Hyun Jik
    Ryu, Jung Min
    Jung, Young Hyun
    Oh, Sang Yub
    Lee, Sei-Jung
    Han, Ho Jae
    [J]. STEM CELLS, 2015, 33 (07) : 2182 - 2195
  • [39] Stabilization of Snail by HIF-1α and TNF-α is required for hypoxia-induced invasion in prostate cancer PC3 cells
    Lei Lv
    Jingdong Yuan
    Tao Huang
    Chuanhua Zhang
    Zhineng Zhu
    Liang Wang
    Guosong Jiang
    Fuqing Zeng
    [J]. Molecular Biology Reports, 2014, 41 : 4573 - 4582
  • [40] L-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1α) in H9c2 cardiomyoblasts
    Bharadwaj, LA
    Davies, GF
    Xavier, IJ
    Ovsenek, N
    [J]. PHARMACOLOGICAL RESEARCH, 2002, 45 (03) : 175 - 181
12345