New p53-based anti-cancer therapeutic strategies

被引：0
作者：
Klas G Wiman
机构：
[1] Karolinska Institute,Microbiology and Tumor Biology Center
来源：
Medical Oncology | 1998年 / 15卷
关键词：
p53; cancer therapy; gene transfer; mutant adenovirus; mutant p53; reactivation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Thep53 gene is frequently mutated in human tumours and therefore an important target for therapeutic intervention. Several p53-based strategies for treatment of cancer are currently under development.p53 gene therapy has resulted in tumour regression in patients with lung cancer. A mutant adenovirus can obliterate tumour cells carrying mutant p53 or lacking p53, but is unable to replicate in normal cells. Furthermore, current studies suggest that reactivation of mutant p53 proteins in tumours using small p53-activating molecules may initiate p53-dependent apoptosis and thus eliminate the tumour.
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页码：222 / 228
页数：6
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