Noise-induced coherent switch

被引：0
作者：
ZhanJiang Yuan
JiaJun Zhang
TianShou Zhou
机构：
[1] Sun Yat-Sen University,School of Life Science
[2] Sun Yat-Sen University,School of Mathematics and Computational Science
来源：
Science in China Series B: Chemistry | 2008年 / 51卷
关键词：
noise; coherent switch; gene toggle switch; gene regulation; synthetic gene network;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Taking the famous genetic toggle switch as an example, we numerically investigated the effect of noise on bistability. We found that extrinsic noise resulting from stochastic fluctuations in synthesis and degradation rates and from the environmental fluctuation in gene regulatory processes can induce coherent switch, and that there is an optimal noise intensity such that the noise not only can induce this switch, but also can amplify a weak input signal. In addition, we found that the intrinsic noise introduced through the Poisson τ-leap algorithm cannot induce such a switch.
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页码：562 / 569
页数：7
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