Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow-up study

被引：0
作者：
Anna Synakiewicz
Anna Stanislawska-Sachadyn
Malgorzata Sawicka-Zukowska
Grazyna Galezowska
Joanna Ratajczyk
Anna Owczarzak
Malgorzata Skuza
Lidia Wolska
Teresa Stachowicz-Stencel
机构：
[1] Medical University of Gdansk,Department of Pediatrics, Hematology and Oncology
[2] Gdansk University of Technology,Department of Molecular Biotechnology and Microbiology
[3] Medical University of Bialystok,Department of Pediatric Oncology and Hematology
[4] Medical University of Gdansk,Department of Environmental Toxicology
[5] Medical University of Gdansk,Department of Clinical Nutrition
[6] The Polish Red Cross Maritime Hospital,Diagnostic Imaging Department
来源：
Amino Acids | 2021年 / 53卷
关键词：
Amino acid profile; Metabolomics; Cancer; Tumor biomarkers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Amino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing to controls. Results suggest that plasma free AA profile may serve as a prognostic biomarker.
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页码：133 / 138
页数：5
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