Usefulness of Toxoplasma gondii recombinant antigens (GRA1, GRA7 and SAG1) in an immunoglobulin G avidity test for the serodiagnosis of toxoplasmosis

被引：0
作者：
H. Pietkiewicz
E. Hiszczyńska-Sawicka
J. Kur
E. Petersen
H. V. Nielsen
M. Paul
M. Stankiewicz
P. Myjak
机构：
[1] Medical University of Gdańsk,Department of Tropical Parasitology, Inter
[2] Gdańsk University of Technology,Faculty Institute of Maritime and Tropical Medicine
[3] Aarhus University Hospital-Skejby,Department of Microbiology
[4] Statens Seruminstitut,Department of Infectious Diseases
[5] Medical University of Poznań,Laboratory of Parasitology
[6] Lincoln University,Department of Tropical Medicine and Parasitology
来源：
Parasitology Research | 2007年 / 100卷
关键词：
Toxoplasmosis; Recombinant Antigen; High Avidity; Affinity Maturation; Avidity Index;
D O I：
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中图分类号：
学科分类号：
摘要：
The precise diagnosis of an acute and recent Toxoplasma infection in pregnant women and the newborn child is important before treatment. This study describes a new Toxoplasma gondii IgG avidity test based on a combination of recombinant GRA1, GRA7 and SAG1 antigens and shows that this test is useful for diagnostic purposes and may replace the lysed, whole-cell antigens. Although more sera need to be tested, the results obtained here suggest that the IgG avidity test performed with rec-antigens correlated more with the stage of a T. gondii infection than the IgG avidity results obtained with the lysed, whole-cell antigen test, the VIDAS Toxo IgG avidity (bioMérieux).
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页码：333 / 337
页数：4
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