The Role of Fluoride in Montmorillonite-Catalyzed RNA Synthesis

被引：0

作者：

Michael F. Aldersley

Prakash C. Joshi

机构：

[1] Rensselaer Polytechnic Institute,New York Center for Astrobiology and the Department of Chemistry and Chemical Biology

来源：

Journal of Molecular Evolution | 2014年 / 78卷

关键词：

Montmorillonite; Activated nucleotides; Fluoride ion; Phosphorofluoridates;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The montmorillonite-catalyzed reactions of the 5′-phosphorimidazolide of adenosine in the presence of fluoride were investigated to complete our study on the effect of salts on this type of reaction. Both anions and cations have been found to influence the oligomerization reactions of the activated nucleotides, being used here as a model system for pre-biotic RNA synthesis. However, in total contrast to the behavior of the activated nucleotides in the presence of montmorillonite and other salts, alkali metal fluorides did not yield any detectable oligomerization products except in very dilute (<0.005 M) solutions of fluoride. Instead, 5′-phosphorofluoridates were formed. Their identity was confirmed by a combination of HPLC, mass spectrometry, synthesis, and NMR.

引用

页码：275 / 278

页数：3

共 27 条

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