Sexual Dimorphisms in Nonalcoholic Fatty Liver Disease

被引：2
作者：
Musto J. [1 ,2 ]
Spengler E.K. [1 ,2 ]
German M.N. [1 ,2 ]
机构：
[1] Division of Gastroenterology and Hepatology, Department of Medicine, 4264 MFCB, 1685 Highland Avenue, Madison, 53705, WI
[2] School of Medicine and Public Health, University of Wisconsin, 4000 MFCB, 1685 Highland Avenue, Madison, 53705, WI
来源：
Current Hepatology Reports | 2021年 / 20卷 / 4期
关键词：
Estrogen; Gender; Metabolic syndrome; Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Sex differences;
D O I：
10.1007/s11901-021-00568-8
中图分类号：
学科分类号：
摘要：
Purpose of Review: This review focuses on how sex differences play a role in the development and progression of NAFLD, describe inconsistencies in current findings, and propose goals for future studies. Recent Findings: NAFLD prevalence and severity is higher in men than in premenopausal women. After menopause, prevalence of NAFLD increases, suggesting a protective effect of estrogen. Androgen excess may also increase the risk of steatosis in women. Furthermore, there is a strong interplay between hormonal changes and development of visceral adiposity and metabolic syndrome, both closely related to NAFLD progression. Summary: Despite advancements in research, our understanding of sexual dimorphism in NAFLD remains incomplete. While results are varied, it is apparent that sex differences with regard to endogenous hormones, reproductive stage, metabolic risk factors, and body fat distribution all play a significant role in the development of NAFLD. Future studies should aim to develop sex-specific therapies to mitigate the rising prevalence of NAFLD. © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021.
引用
收藏
页码：97 / 107
页数：10
相关论文
共 97 条
  • [61] Dhindsa S., Ghanim H., Batra M., Dandona P., Hypogonadotropic hypogonadism in men with diabesity, Diabetes Care, 41, pp. 1516-1525, (2018)
  • [62] Dhindsa S., Ghanim H., Batra M., Kuhadiya N.D., Abuaysheh S., Sandhu S., Et al., Insulin resistance and inflammation in hypogonadotropic hypogonadism and their reduction after testosterone replacement in men with type 2 diabetes, Diabetes Care, 39, pp. 82-91, (2016)
  • [63] Florentino G.S., Cotrim H.P., Vilar C.P., Florentino A.V., Guimaraes G.M., Barreto V.S., Nonalcoholic fatty liver disease in menopausal women, Arq Gastroenterol, 50, pp. 180-185, (2013)
  • [64] Sorensen M.B., Rosenfalck A.M., Hojgaard L., Ottesen B., Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy, Obes Res, 9, pp. 622-626, (2001)
  • [65] McKenzie J., Fisher B.M., Jaap A.J., Stanley A., Paterson K., Sattar N., Effects of HRT on liver enzyme levels in women with type 2 diabetes: a randomized placebo-controlled trial, Clin Endocrinol (Oxf), 65, pp. 40-44, (2006)
  • [66] Tian G.X., Sun Y., Pang C.J., Tan A.H., Gao Y., Zhang H.Y., Et al., Oestradiol is a protective factor for non-alcoholic fatty liver disease in healthy men, Obes Rev, 13, pp. 381-387, (2012)
  • [67] Hallajzadeh J., Khoramdad M., Izadi N., Karamzad N., Almasi-Hashiani A., Ayubi E., Et al., Metabolic syndrome and its components in premenopausal and postmenopausal women: a comprehensive systematic review and meta-analysis on observational studies, Menopause, 25, pp. 1155-1164, (2018)
  • [68] Pedersen S.B., Kristensen K., Hermann P.A., Katzenellenbogen J.A., Richelsen B., Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution, J Clin Endocrinol Metab, 89, pp. 1869-1878, (2004)
  • [69] Park Y.M., Pereira R.I., Erickson C.B., Swibas T.A., Cox-York K.A., van Pelt R.E., Estradiol-mediated improvements in adipose tissue insulin sensitivity are related to the balance of adipose tissue estrogen receptor α and β in postmenopausal women, Plos One, 12, (2017)
  • [70] Ayonrinde O.T., Olynyk J.K., Beilin L.J., Mori T.A., Pennell C.E., de Klerk N., Et al., Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease, Hepatology, 53, pp. 800-809, (2011)
12345678910