Effect of Hypothalamic Proline-Rich-Polypeptide on Voltage-Gated Ca2+ Currents in Retinal Ganglion Cells

被引：0
作者：
Abram Akopian
Armen Galoyan
机构：
[1] New York University School of Medicine,Department of Ophthalmology
[2] Buniatian Institute of Biochemistry NAS RA,undefined
来源：
Neurochemical Research | 2003年 / 28卷
关键词：
Neurotrophins; retina; Ca channel; patch clamp; spike;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neurotrophins are molecules that regulate neuronal survival, nervous system plasticity, and many other physiological functions of neuronal and glial cells. Here we studied the physiological action of a novel neurosecretory polypeptide proline-rich polypeptide (PRP), isolated from bovine neurohypophysis neurosecretory granules, on voltage-gated Ca currents and spike firing activity of retinal ganglion cells. PRP reversibly increased high voltage–activated L-type Ca current, but was without effect on low voltage–activated T-type current. PRP also increased the spike after hyperpolarization and reduced the frequency of spike firing, most likely by affecting a Ca-dependent potassium current.
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页码：1867 / 1871
页数：4
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