Impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms on vincristine-induced neurotoxicity

被引:0
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作者
Romain Guilhaumou
Caroline Solas
Veronique Bourgarel-Rey
Sylvie Quaranta
Angelique Rome
Nicolas Simon
Bruno Lacarelle
Nicolas Andre
机构
[1] Aix-Marseille Univ,Laboratoire de Pharmacocinétique et Toxicologie
[2] CRO2,Service d’Oncologie Pédiatrique
[3] INSERM,Laboratoire de Pharmacologie Médicale et Clinique
[4] UMR 911,undefined
[5] Hôpital de la Timone,undefined
[6] Hôpital de la Timone,undefined
[7] Hôpital de la Timone,undefined
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关键词
Vincristine; Neurotoxicity; Pediatric; Pharmacogenetics; Pharmacokinetics; Intracellular concentration;
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学科分类号
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页码:1633 / 1638
页数:5
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