Lipid metabolism in Alzheimer’s disease

被引：0
作者：
Qiang Liu
Juan Zhang
机构：
[1] University of Science and Technology of China,CAS Key Laboratory of Brain Function and Disease and School of Life Sciences
[2] Washington University School of Medicine,Department of Genetics
来源：
Neuroscience Bulletin | 2014年 / 30卷
关键词：
brain aging; lipid metabolism; Alzheimer’s disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD), and other central nervous system insults. The brain contains thousands of lipid species, but the complex lipid compositional diversity and the function of each of lipid species are currently poorly understood. This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis.
引用
收藏
页码：331 / 345
页数：14
相关论文
共 741 条
  • [81] Peters MM(2002)Cholesterol-dependent gammasecretase activity in buoyant cholesterol-rich membrane microdomains Neurobiol Dis 9 11-27694
  • [82] Cheng H(2004)GM1 ganglioside regulates the proteolysis of amyloid precursor protein Mol Psychiatry 9 946-43256
  • [83] Bao J(2001)A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer’s disease Neurobiol Dis 8 890-893
  • [84] Liu Q(2003)Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion J Biol Chem 278 27688-202
  • [85] Zerbinatti CV(2005)The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease J Biol Chem 280 43243-24990
  • [86] Zhang J(2009)LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins J Lipid Res 50 885-329
  • [87] Hoe HS(2005)Cholesterol and amyloid beta fibrillogenesis Subcell Biochem 38 179-831
  • [88] Wang B(2001)Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid J Biol Chem 276 24985-912
  • [89] Cole SL(2011)Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer’s disease Brain Pathol 21 321-238
  • [90] Madra M(2012)Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer’s disease: structural insight Neurobiol Aging 33 831 e821-852
45678910111213