Lipid metabolism in Alzheimer’s disease

被引：0
作者：
Qiang Liu
Juan Zhang
机构：
[1] University of Science and Technology of China,CAS Key Laboratory of Brain Function and Disease and School of Life Sciences
[2] Washington University School of Medicine,Department of Genetics
来源：
Neuroscience Bulletin | 2014年 / 30卷
关键词：
brain aging; lipid metabolism; Alzheimer’s disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD), and other central nervous system insults. The brain contains thousands of lipid species, but the complex lipid compositional diversity and the function of each of lipid species are currently poorly understood. This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis.
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页码：331 / 345
页数：14
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