Developments in Treatment of Esophageal/Gastric Cancer

被引：0
作者：
Wei Liu
Xiaodong Zhang
Weijing Sun
机构：
[1] Hebei Medical University,
[2] Peking University School of Oncology,undefined
[3] Beijing Cancer Hospital and Institute,undefined
[4] Abramson Cancer Center of the University of Pennsylvania,undefined
来源：
Current Treatment Options in Oncology | 2008年 / 9卷
关键词：
Gastric Cancer; Overall Survival; Bevacizumab; Docetaxel; Esophageal Cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Advances have been achieved in the therapy of esophageal and gastric cancer (including carcinoma of gastroesophageal junction); however, it poses a continuous challenge to treat this highly virulent disease effectively. The concept of the benefits of perioperative (pre- or/and post-) therapy (chemotherapy or chemoradiation) has been accepted and confirmed by several large randomized phase III studies globally in different regions, settings, and patient population (INT 0116, MAGIC, ACTS-GC, and JCOG 9907). Efficacy of combination of newer cytotoxic chemotherapy agents has been demonstrated with increased progression-free survival and overall survival in patients with metastatic disease (e.g., REAL-2, V325, SPIRITS, and COG9912). Encouraging results have been shown from recent preliminary data with biological and target-oriented agents in the treatment of esophageal and gastric cancer.
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页码：375 / 387
页数：12
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