Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences

被引:0
|
作者
Cosby G. Arnold
Layne Dylla
Andrew A. Monte
Kennon Heard
Susan Heard
Angelo D’Alessandro
Kate Reynolds
Richard Dart
Barry Rumack
Brandon Sonn
机构
[1] University of Colorado School of Medicine,Department of Emergency Medicine
[2] University of Colorado Denver-Anschutz Medical Center,Rocky Mountain Poison & Drug Center
[3] Denver Health and Hospital Authority,Division of Bioinformatics & Personalized Medicine
[4] University of Colorado School of Medicine,Department of Pediatrics
[5] University of Colorado School of Medicine,undefined
来源
Journal of Medical Toxicology | 2022年 / 18卷
关键词
Acetaminophen; Adducts; Hepatotoxicity; Metabolomics; Therapeutic; Tylenol;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:297 / 310
页数:13
相关论文
共 6 条
  • [1] Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences
    Arnold, Cosby G.
    Dylla, Layne
    Monte, Andrew A.
    Heard, Kennon
    Heard, Susan
    D'Alessandro, Angelo
    Reynolds, Kate
    Dart, Richard
    Rumack, Barry
    Sonn, Brandon
    JOURNAL OF MEDICAL TOXICOLOGY, 2022, 18 (04) : 297 - 310
  • [2] What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)?
    Leeming, Michael G.
    Gamon, Luke F.
    Wille, Uta
    Donald, William A.
    O'Hair, Richard A. J.
    CHEMICAL RESEARCH IN TOXICOLOGY, 2015, 28 (11) : 2224 - 2233
  • [3] Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine
    Tan, Su Ching
    New, Lee Sun
    Chan, Eric C. Y.
    TOXICOLOGY LETTERS, 2008, 180 (03) : 174 - 181
  • [4] A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine and glutathione
    Klopcic, Ivana
    Poberznik, Matic
    Mavri, Janez
    Dolenc, Marija Sollner
    CHEMICO-BIOLOGICAL INTERACTIONS, 2015, 242 : 407 - 414
  • [5] Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation
    Santoh, Masataka
    Sanoh, Seigo
    Ohtsuki, Yuya
    Ejiri, Yoko
    Kotake, Yaichiro
    Ohta, Shigeru
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 486 (03) : 639 - 644
  • [6] An Indole Derivative Protects Against Acetaminophen-Induced Liver Injury by Directly Binding to N-Acetyl-p-Benzoquinone Imine in Mice
    Park, Ji-Hoon
    Seo, Kang-Sik
    Tadi, Surendar
    Ahn, Bong-Hyun
    Lee, Jung-Uee
    Heo, Jun-Young
    Han, Jeongsu
    Song, Myoung-Sub
    Kim, Soon-Ha
    Yim, Yong-Hyeon
    Choi, Hueng-Sik
    Shong, Minho
    Kweon, GiRyang
    ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (14) : 1713 - 1722