Mechanisms of endothelial flow sensing

被引：0
|
作者：
Claire Aitken
Vedanta Mehta
Martin A. Schwartz
Ellie Tzima
机构：
[1] University of Oxford,Wellcome Centre for Human Genetics, Radcliffe Department of Medicine
[2] Yale University,Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and Departments of Cell Biology and Biomedical Engineering
来源：
Nature Cardiovascular Research | 2023年 / 2卷
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学科分类号：
摘要：
Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert physical forces into biochemical signals, a process termed mechanotransduction. This Review discusses our understanding of endothelial flow sensing and suggests important questions for future investigation.
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页码：517 / 529
页数：12
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