Gadolinium blocks proton-activated currents in isolated Purkinje cells

被引：0
|
作者：
I. N. Sharonova
A. Yu. Dvorzhak
V. S. Vorobjov
机构：
[1] Russian Academy of Medical Sciences,Department of Brain Studies, Research Center of Neurology
来源：
Bulletin of Experimental Biology and Medicine | 2008年 / 145卷
关键词：
proton-activated channels; gadolinium; cerebellum; potential fixation method;
D O I：
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学科分类号：
摘要：
Patch-clamp and concentration jump studies showed that gadolinium ions dose-dependently reduced the amplitude of proton-activated currents (pH 6.5) in isolated Purkinje cells (gadolinium concentration producing a half-maximum effect was 69 µM for the peak and 8 µM for the stationary component of the current). The magnitude of the block did not depend on membrane potential at negative clamping potentials. Gadolinium blockade of activated receptor was more rapid and intensive in comparison with blocking of silent receptor.
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