Long non-coding RNAs: new players in cell differentiation and development

被引：0
作者：
Alessandro Fatica
Irene Bozzoni
机构：
[1] Sapienza University of Rome,Department of Biology and Biotechnology “Charles Darwin”
[2] Institute of Molecular Biology and Pathology of the National Research Council,undefined
[3] Istituto Pasteur Fondazione Cenci Bolognetti,undefined
[4] Center for Life Nano Science @Sapienza,undefined
[5] Istituto Italiano di Tecnologia,undefined
[6] Sapienza University of Rome,undefined
来源：
Nature Reviews Genetics | 2014年 / 15卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Genomes of multicellular organisms produce thousands of different long non-coding RNA (lncRNA) species.lncRNAs have crucial roles in gene expression control during developmental and differentiation processes.lncRNAs can regulate gene expression by several mechanisms in both the nucleus and the cytoplasm.lncRNAs drive the formation of ribonucleoprotein complexes and guide them to specific targets to regulate gene expression.Different in vitro and in vivo systems have shown the importance of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis.lncRNAs can form regulative networks with other RNA species, such as microRNAs and mRNAs.
引用
收藏
页码：7 / 21
页数：14
相关论文
共 267 条
  • [71] Grummt I(2013) in X chromosome inactivation Genes Dev. 27 1260-1445
  • [72] Chu C(2013)Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing Cell Rep. 5 3-337
  • [73] Qu K(2000)Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway Dev. Biol. 220 333-541
  • [74] Zhong FL(2011)Disruption of imprinted X inactivation by parent-of-origin effects at PLoS Genet. 7 e1002071-3093
  • [75] Artandi SE(2010)Regulation of imprinted X-chromosome inactivation in mice by Nature 464 1071-123
  • [76] Chang HY(2010)The long noncoding RNA, Nature Genet. 42 1113-1189
  • [77] Hung T(2009), is a molecular switch for X chromosome inactivation Nature 458 223-628
  • [78] Sun S(2008) RNA is a potent suppressor of hematologic cancer in mice Genome Res. 9 1433-172
  • [79] Wang X(2010)Regional loss of imprinting and growth deficiency in mice with a targeted deletion of RNA 16 324-482
  • [80] Yang L(2012)The non-coding Nature Rev. Neurosci. 13 528-1040
3456789101112