Long non-coding RNAs: new players in cell differentiation and development

被引：0
作者：
Alessandro Fatica
Irene Bozzoni
机构：
[1] Sapienza University of Rome,Department of Biology and Biotechnology “Charles Darwin”
[2] Institute of Molecular Biology and Pathology of the National Research Council,undefined
[3] Istituto Pasteur Fondazione Cenci Bolognetti,undefined
[4] Center for Life Nano Science @Sapienza,undefined
[5] Istituto Italiano di Tecnologia,undefined
[6] Sapienza University of Rome,undefined
来源：
Nature Reviews Genetics | 2014年 / 15卷
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摘要：
Genomes of multicellular organisms produce thousands of different long non-coding RNA (lncRNA) species.lncRNAs have crucial roles in gene expression control during developmental and differentiation processes.lncRNAs can regulate gene expression by several mechanisms in both the nucleus and the cytoplasm.lncRNAs drive the formation of ribonucleoprotein complexes and guide them to specific targets to regulate gene expression.Different in vitro and in vivo systems have shown the importance of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis.lncRNAs can form regulative networks with other RNA species, such as microRNAs and mRNAs.
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页码：7 / 21
页数：14
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