Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients

被引:0
作者
Usman Arshad
Su-arpa Ploylearmsaeng
Mats O. Karlsson
Oxana Doroshyenko
Dorothee Langer
Edgar Schömig
Sabine Kunze
Semih A. Güner
Roman Skripnichenko
Sami Ullah
Ulrich Jaehde
Uwe Fuhr
Alexander Jetter
Max Taubert
机构
[1] University of Cologne,Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology
[2] Uppsala University,Department of Pharmaceutical Biosciences
[3] University Hospital Cologne,Department of Radiotherapy
[4] University of Bonn,Institute of Pharmacy, Clinical Pharmacy
[5] University Hospital Zurich,Department of Clinical Pharmacology and Toxicology
[6] University of Zurich,undefined
来源
Cancer Chemotherapy and Pharmacology | 2020年 / 85卷
关键词
5-Fluorouracil; Pharmacokinetics; Pharmacodynamics; Pharmacogenetics; Myelosuppression;
D O I
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中图分类号
学科分类号
摘要
引用
收藏
页码:711 / 722
页数:11
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