Electron-immunocytochemical localization of P2X1 receptors in the rat cerebellum

被引：0
|
作者：
A. Loesch
Geoffrey Burnstock
机构：
[1] Department of Anatomy and Developmental Biology,
[2] University College London,undefined
[3] Gower Street,undefined
[4] London WC1E 6BT,undefined
[5] UK Tel.: +44 171 504 2215; Fax: +44 171 380 7349,undefined
[6] Autonomic Neuroscience Institute,undefined
[7] Royal Free Hospital School of Medicine,undefined
[8] Rowland Hill Street,undefined
[9] London NW3 2PF,undefined
[10] UK,undefined
来源：
Cell and Tissue Research | 1998年 / 294卷
关键词：
Key words P2X1 receptor; Ultrastructure; Cerebellum; Rat (Wistar);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The distribution of the P2X1 subtype of purinoceptors associated with the extracellular activities of ATP was studied in the rat cerebellum at the electron-microscope level. Receptors were labelled with peroxidase-antiperoxidase and the avidin-biotin-peroxidase complex for immunocytochemistry. Immunoreactivity to P2X1 receptors was localized in subpopulations of synapses between varicosities of parallel fibres of granule cells and dendritic spines of Purkinje cells. Unlabelled varicosities of parallel fibres formed asymmetric synapses with labelled dendritic spines, whereas labelled varicosities of parallel fibres formed asymmetric synapses with unlabelled dendritic spines. P2X1 immunoreactivity was also localized in some astrocyte processes. The functional significance of these findings is discussed.
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页码：253 / 260
页数：7
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