Prevalence and associated risk factors of Strongyloides stercoralis infection in Lower Myanmar

被引：8
作者：
Aung M.P.P.T.H.H. [1 ]
Hino A. [2 ]
Oo K.M. [1 ]
Win K.K. [1 ]
Maruyama H. [2 ]
Htike W.W. [1 ]
Nagayasu E. [2 ]
机构：
[1] Department of Microbiology, University of Medicine 1, Lanmadaw Township, No. 245 Myoma Kyaung Street, Yangon
[2] Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki
来源：
Tropical Medicine and Health | / 46卷 / 1期
基金：
日本学术振兴会;
关键词：
Agar plate culture; Molecular assays; Myanmar; Prevalence; Strongyloides stercoralis;
D O I：
10.1186/s41182-018-0126-5
中图分类号：
学科分类号：
摘要：
Background: Strongyloidiasis is prevalent in Southeast Asian regions along with other soil-transmitted helminthiases, but only limited present-day data was available for Myanmar. Methods: A prevalence survey for Strongyloides stercoralis infection was conducted among villagers in rural areas of three townships located in the Lower Myanmar during 2014-2016 by agar plate culture method in combination with specific identification by molecular assays. Risk factors associated with S. stercoralis infection were assessed by analyzing questionnaires obtained from study participants. Results: Strongyloides stercoralis was identified in 40 out of 703 participants (5.7% overall prevalence). The highest prevalence (14.4%) was observed in Htantabin, while other two communities (Thabaung and Thanlyin) had much lower prevalence (2.2 and 2.5%, respectively). Infection was relatively rare (1.2%) in younger generations under 20 years compared to older generations (9.5%). Even in Htantabin, none of the female residents under age 40 (n = 33) had infection. In adult Htantabin residents, those who answered that they do not wear shoes regularly had an elevated risk of infection (odds ratio = 2.50, 95% confidence interval = 1.03-6.08). Conclusions: This study showed that there is still an on-going transmission of strongyloidiasis in Lower Myanmar. It is highly desirable that the soil should be free of fecal contamination by improving the management of fecal waste. Meanwhile, health education to promote shoe-wearing would be beneficial to reduce the risk of transmission, especially for those who have frequent and intense contact with soil. © 2018 The Author(s).
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  • [1] Olsen A., Van Lieshout L., Marti H., Polderman T., Polman K., Steinmann P., Et al., Strongyloidiasis-the most neglected of the neglected tropical diseases?, Trans R Soc Trop Med Hyg, 103, pp. 967-972, (2009)
  • [2] Hall A., Conway D.J., Anwar K.S., Rahman M.L., Strongyloides stercoralis in an urban slum community in Bangladesh: Factors independently associated with infection, Trans R Soc Trop Med Hyg, 88, pp. 527-530, (1994)
  • [3] Bisoffi Z., Buonfrate D., Montresor A., Et al., Strongyloides stercoralis: A plea for action, PLoS Negl Trop Dis, 7, (2013)
  • [4] Schar F., Trostdorf U., Giardina F., Khieu V., Muth S., Marti H., Et al., Strongyloides stercoralis: Global distribution and risk factors, PLoS Negl Trop Dis, 7, (2013)
  • [5] Bethony J., Brooker S., Albonico M., Geiger S.M., Loukas A., Diemert D., Et al., Soil-transmitted helminth infections: Ascariasis, trichuriasis, and hookworm, Lancet, 367, pp. 1521-1532, (2006)
  • [6] Grove D.I., Human strongyloidiasis, Adv Parasitol, 38, pp. 251-309, (1996)
  • [7] Zaha O., Hirata T., Kinjo F., Saito A., Fukuhara H., Efficacy of ivermectin for chronic strongyloidiasis: Two single doses given 2 weeks apart, J Infect Chemother, 8, pp. 94-98, (2002)
  • [8] Dunn J.C., Bettis A.A., Wyine N.Y., Et al., A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: Epidemiology of infection with a focus on adults, Parasit Vectors, 10, (2017)
  • [9] Nagayasu E., Aung M., Hortiwakul T., Hino A., Tanaka T., Higashiarakawa M., Et al., A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny, Sci Rep, 7, (2017)
  • [10] Arakaki T., Iwanaga M., Kinjo F., Saito A., Asato R., Ikeshiro T., Efficacy of agar-plate culture in detection of Strongyloides stercoralis infection, J Parasitol, 76, pp. 425-428, (1990)
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