Vocal cord palsy after vincristine treatment in a child and the inefficacy of glutamic acid in the prevention of relapse: A case report

被引：10

作者：

Piero Farruggia

Serena Tropia

Sonia Cannella

Giuseppa Bruno

Gaspare Oddo

Paolo D’Angelo

机构：

[1] Oncology Department, Pediatric Hematology and Oncology Unit, A.R.N.A.S. Ospedali Civico, di Cristina e Benfratelli, Palermo, 90127

[2] Clinic Department, Pharmaceutical Laboratory, A.R.N.A.S. Ospedali Civico, di Cristina e Benfratelli, Palermo, 90127

来源：

Journal of Medical Case Reports | / 6卷 / 1期

关键词：

Glutamic acid; Neuropathy; Vincristine; Vocal cord palsy;

D O I：

10.1186/1752-1947-6-128

中图分类号：

学科分类号：

摘要：

Introduction: Vincristine is an antineoplastic drug with a well known efficacy for the treatment of acute lymphoblastic leukemia and many solid tumors. No more than 20 pediatric patients with vincristine-induced vocal cord palsy have been reported, and to the best of our knowledge this is the first case where glutamic acid was administered with the aim of preventing a relapse of laryngeal dysfunction. Case presentation: The larynx paralysis presented with hoarseness and stridor in a Caucasian 18-month-old girl and spontaneously resolved in about a month. In order to administer a subsequent full dose of vincristine, our patient received oral glutamic acid whose efficacy against vincristine neurological side effects has been previously reported. Conclusions: Since in our patient the amino acid proved to be ineffective in the prevention of laryngeal paralysis relapse, we suggest that a dose reduction of vincristine should be preferred by oncologists as an initial approach after a case of drug-induced vocal cord palsy. © 2012 Farruggia et al.; licensee BioMed Central Ltd.

引用

共 10 条

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