The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy

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作者：

Lorella Pascolo

Alessandra Gianoncelli

Giulia Schneider

Murielle Salomé

Manuela Schneider

Carla Calligaro

Maya Kiskinova

Mauro Melato

Clara Rizzardi

机构：

[1] IRCCS Burlo Garofolo,Institute for Maternal and Child Health

[2] Elettra-Sincrotrone Trieste S.C.p.a.,Department of Anatomical Pathology, Department of Pathology and Forensic Medicine

[3] University of Trieste,Unit of Pathology, ASS n. 2 “Isontina” Department of Anatomical Pathology

[4] European Synchrotron Radiation Facility,undefined

[5] Hospital of Monfalcone,undefined

[6] Servizio Diagnostica Veterinaria,undefined

[7] University of Udine,undefined

来源：

Scientific Reports | / 3卷

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摘要：

Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed to its particular physico-chemical characteristics and one of them is the presence of and ability to adsorb iron, which may cause an alteration of iron homeostasis in the tissue. This observational study reports a combination of advanced synchrotron-based X-ray imaging and micro-spectroscopic methods that provide correlative morphological and chemical information for shedding light on iron mobilization features during asbestos permanence in lung tissue. The results show that the processes responsible for the unusual distribution of iron at different stages of interaction with the fibres also involve calcium, phosphorus and magnesium. It has been confirmed that the dominant iron form present in asbestos bodies is ferritin, while the concurrent presence of haematite suggests alteration of iron chemistry during asbestos body permanence.

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