Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma

被引：0
作者：
Naoto Kuroda
Naoki Kanomata
Tadanori Yamaguchi
Yoshiaki Imamura
Chisato Ohe
Noriko Sakaida
Ondrej Hes
Michal Michal
Taro Shuin
Gang-Hong Lee
机构：
[1] Kochi Red Cross Hospital,Department of Diagnostic Pathology
[2] Kawasaki Medical School,Department of Pathology
[3] Ayabe City Hospital,Department of Pathology
[4] University of Fukui Hospital,Division of Surgical Pathology
[5] Kansai Medical University Hirakata Hospital,Department of Pathology
[6] Charles University Hospital Plzen,Department of Pathology
[7] Kochi University,Department of Urology, Kochi Medical School
[8] Kochi University,Department of Pathology, Kochi Medical School
来源：
Medical Molecular Morphology | 2011年 / 44卷
关键词：
S100A1; Renal oncocytoma; Oncocytic papillary RCC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
S100A1 is a calcium-binding protein and a member of the S100 family. Recently, S100A1 immunohistochemistry may be an available marker in the differential diagnosis between renal oncocytoma and chromophobe renal cell carcinoma (RCC). However, there are no reports on S100A1 expression in oncocytic papillary RCC that has been recently identified. In this article, we immunohistochemically examined the expression of S100A1 protein in 18 renal tumors including 4 renal oncocytoma, 10 chromophobe RCCs, and 4 oncocytic papillary RCCs. All the cases of renal oncocytoma and oncocytic papillary RCC showed a positive reaction for S100A1 with cytoplasmic pattern. In chromophobe RCC, 3 of 4 tumors with typical variant and 4 of 6 tumors in eosinophilic variant were completely negative for S100A1. Finally, S100A1 immunohistochemistry may be useful in distinguishing renal oncocytoma from chromophobe RCC, but it may be of no use in the differential diagnosis between renal oncocytoma and oncocytic papillary RCC.
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页码：111 / 115
页数：4
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