Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

被引：0
作者：
H Lage
H Helmbach
M Dietel
D Schadendorf
机构：
[1] Institute of Pathology,
[2] Charité,undefined
[3] Campus Mitte,undefined
[4] Humboldt University Berlin,undefined
[5] Clinical Cooperation Unit Dermatooncology at the DKFZ and Clinics Mannheim,undefined
[6] University Heidelberg,undefined
来源：
British Journal of Cancer | 2000年 / 82卷
关键词：
melanoma; drug resistance; etoposide; cisplatin; fotemustine; vindesine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms. © 2000 Cancer Research Campaign
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页码：488 / 491
页数：3
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