Somatostatin, Somatostatin Receptors, and Pancreatic Cancer

被引：0
作者：
Min Li
William E. Fisher
Hee Joon Kim
Xiaoping Wang
Charles F. Brunicardi
Changyi Chen
Qizhi Yao
机构：
[1] Baylor College of Medicine and the Methodist Hospital,Elkins Pancreas Center, Michael E. DeBakey Department of Surgery
[2] Baylor College of Medicine and the Methodist Hospital,Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery
[3] University of Texas at Houston Medical School,undefined
来源：
World Journal of Surgery | 2005年 / 29卷
关键词：
Pancreatic Cancer; Pancreatic Cancer Cell; Pancreatic Cancer Cell Line; Human Pancreatic Adenocarcinoma; SSTR Subtype;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.
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页码：293 / 296
页数：3
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