Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance

被引:0
作者
Serena del Favero
Hamilton Roschel
Guilherme Artioli
Carlos Ugrinowitsch
Valmor Tricoli
André Costa
Renato Barroso
Ana Lua Negrelli
Maria Concepción Otaduy
Cláudia da Costa Leite
Antonio Herbert Lancha-Junior
Bruno Gualano
机构
[1] University of Sao Paulo,School of Physical Education and Sport
[2] University of Sao Paulo,School of Medicine, Division of Radiology
来源
Amino Acids | 2012年 / 42卷
关键词
Betaine supplementation; Creatine supplementation; Maximal muscle strength; Muscle power output; Phosphorylcreatine content;
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学科分类号
摘要
We aimed to investigate the role of betaine supplementation on muscle phosphorylcreatine (PCr) content and strength performance in untrained subjects. Additionally, we compared the ergogenic and physiological responses to betaine versus creatine supplementation. Finally, we also tested the possible additive effects of creatine and betaine supplementation. This was a double-blind, randomized, placebo-controlled study. Subjects were assigned to receive betaine (BET; 2 g/day), creatine (CR; 20 g/day), betaine plus creatine (BET + CR; 2 + 20 g/day, respectively) or placebo (PL). At baseline and after 10 days of supplementation, we assessed muscle strength and power, muscle PCr content, and body composition. The CR and BET + CR groups presented greater increase in muscle PCr content than PL (p = 0.004 and p = 0.006, respectively). PCr content was comparable between BET versus PL (p = 0.78) and CR versus BET + CR (p = 0.99). CR and BET + CR presented greater muscle power output than PL in the squat exercise following supplementation (p = 0.003 and p = 0.041, respectively). Similarly, bench press average power was significantly greater for the CR-supplemented groups. CR and BET + CR groups also showed significant pre- to post-test increase in 1-RM squat and bench press (CR: p = 0.027 and p < 0.0001; BET + CR: p = 0.03 and p < 0.0001 for upper- and lower-body assessments, respectively) No significant differences for 1-RM strength and power were observed between BET versus PL and CR versus BET + CR. Body composition did not differ between the groups. In conclusion, we reported that betaine supplementation does not augment muscle PCr content. Furthermore, we showed that betaine supplementation combined or not with creatine supplementation does not affect strength and power performance in untrained subjects.
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页码:2299 / 2305
页数:6
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