Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis

被引：18
作者：
Amin K. [1 ,2 ]
Issa S.M. [1 ]
Ali K.M. [1 ]
Aziz M.I. [1 ]
Hama Amieen H.M. [3 ]
Bystrom J. [4 ]
Janson C. [2 ]
机构：
[1] Department of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani, Sulaimanyah
[2] Department of Medical Science, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala
[3] Otolaryngology Center, Sulaimani Teaching Hospital, Sulaimanyah
[4] Expermiental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London, Queen Mary, University of London, Charterhouse Square, London
来源：
Clinical and Molecular Allergy | / 18卷 / 1期
关键词：
Allergic rhinitis; ECP; IgE; IL-17; IL-33; Immune system;
D O I：
10.1186/s12948-020-00117-6
中图分类号：
学科分类号：
摘要：
Background: The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients. Subjects and methods: Blood samples were taken from 88 AR patients and 88 healthy controls (HC). Each sample was analysed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using ELISA test. Results: There was no significant difference between AR patients and the control group in age and gender. Levels of eosinophils, IgE, ECP, IL-17, IL-33 and the total symptom scores were significantly higher in AR patients than the HC (P = 0.0001). Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient. Conclusions: Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies. © 2020 The Author(s).
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