Voltammetric determination of mifepristone at a DNA-modified carbon paste electrode

A new strategy for the preparation of a DNA-modified carbon paste electrode is developed. It is found that the anodic response of mifepristone is greatly enhanced at the dsDNA-modified carbon paste electrode comparing with that obtained at the bare electrode, while the response at a ssDNA-modified electrode is similar to bare electrode. So the dsDNA-modified electrode is employed as a sensitive biosensor for the detection of mifepristone. A linear dependence of the peak currents on the concentration is observed in the range 2.0 × 10–7∼ 2.0 × 10–6 mol/L, with a detection limit of 1.0 × 10–7 mol/L. The relative standard deviation is 4.3% for six successive determinations of 1.0 × 10–6 mol/L mifepristone. The determination of mifepristone tablets is carried out and satisfactory results are obtained.