A case of peripheral T-cell lymphoma presenting with acute liver failure

被引：2

作者：

Konno N. ^{[1
]}

Takahashi A. ^{[1
]}

Watanabe K. ^{[2
]}

Katsushima F. ^{[1
]}

Monoe K. ^{[1
]}

Kanno Y. ^{[1
]}

Saito H. ^{[1
]}

Abe K. ^{[2
]}

Ohira H. ^{[1
]}

机构：

[1] Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima 960-1295

[2] Department of Gastroenterology, Ohara General Hospital, Fukushima 960-8611

来源：

Clinical Journal of Gastroenterology | 2012年 / 5卷 / 1期

关键词：

Acute liver failure; Hemophagocytic syndrome; Peripheral T-cell lymphoma;

D O I：

10.1007/s12328-011-0267-0

中图分类号：

学科分类号：

摘要：

A 68-year-old woman was evaluated by her primary physician for swelling and pain in the right neck. Treatment with antibiotics failed to achieve any improvement. Two weeks later, she was hospitalized to the gastroenterology department because of liver dysfunction and pneumonia. Disseminated intravascular coagulation (DIC) was diagnosed, and protease inhibitor and steroid pulse therapy were started. She was transferred to our department for further evaluation the following day. Bone marrow examination revealed hemophagocytosis and infiltration of CD3-positive cells. Multiple masses were identified in the liver. Her prothrombin time was 35.7% of the standard value 17 days from disease onset, despite improvement of DIC. She was diagnosed with acute liver failure based on the Japanese diagnostic criteria. Her general condition worsened quickly, which prevented use of chemotherapy, and she died after a total course of 19 days. Autopsy revealed atypical lymphocytes in the liver. The diagnosis was peripheral T-cell lymphoma. © 2011 Springer.

引用

页码：31 / 34

页数：3

共 20 条

[1]

Lymphoma Study Group of Japanese Pathologists, Pathol Int., 50, pp. 696-702, (2000)

[2]

Gallamini A., Stelitano C., Calvi R., Bellei M., Mattei D., Vitolo U., Morabito F., Martelli M., Brusamolino E., Iannitto E., Zaja F., Cortelazzo S., Rigacci L., Devizzi L., Todeschini G., Santini G., Brugiatelli M., Federico M., Peripheral T-cell lymphoma unspecified (PTCL-U): A new prognostic model from a retrospective multicentric clinical study, Blood, 103, 7, pp. 2474-2479, (2004)

[3]

Maher M.M., McDermott S.R., Fenlon H.M., Conroy D., O'Keane J.C., Carney D.N., Et al., Imaging of primary non-Hodgkin's lymphoma of the liver, Clin Radiol, 56, pp. 295-301, (2001)

[4]

Gazelle G.S., Lee M.J., Hahn P.F., Goldberg M.A., Rafaat N., Mueller P.R., US, CT, and MRI of primary and secondary liver lymphoma, Journal of Computer Assisted Tomography, 18, 3, pp. 412-415, (1994)

[5]

Rowbotham D., Wendon J., Williams R., Acute liver failure secondary to hepatic infiltration: A single centre experience of 18 cases, Gut, 42, 4, pp. 576-580, (1998)

[6]

Hino T., Sata M., Arima N., Nouno R., Kumashiro R., Koga Y., Uchimura Y., Yoshitake M., Sakisaka S., Kojiro M., Tanikawa K., A Case of Malignant Lymphoma with Hemophagocytic Syndrome Presenting as Hepatic Failure, Kurume Medical Journal, 44, 1, pp. 53-60, (1997)

[7]

Kusano H., Higaki K., Kondo R., Sakai T., Kage M., Oshima K., Et al., Hepatosplenic T-cell lymphoma presenting as untreatable hepatic failure and hemophagocytic syndrome, Kanzo, 51, pp. 28-34, (2010)

[8]

Salo J., Nomdedeu B., Bruguera M., Ordi J., Gines P., Castells A., Vilella A., Rodes J., Acute liver failure due to non-Hodgkin's lymphoma, American Journal of Gastroenterology, 88, 5, pp. 774-776, (1993)

[9]

Thompson D.R., Faust T.W., Stone M.J., Polter D.E., Hepatic failure as the presenting manifestation of malignant lymphoma, Clinical Lymphoma, 2, 2, pp. 123-128, (2001)

[10]

Haider F.S., Smith R., Khan S., Primary hepatic lymphoma presenting as fulminant hepatic failure with hyperferritinemia: A case report, J Med Case Reports, 2, (2008)

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