Pulsatile gonadotropin-releasing hormone treatment

Background: Pulsatile gonadotropin-releasing hormone (GnRH) therapy is an option for ovulation induction in patients with central hypothalamic functional disorders, which is often only initiated as second-line treatment due to the alleged effort involved in treatment. Objective: The indications, course and results of a standardized pulsatile GnRH treatment are presented in order to demonstrate the value of this form of treatment. Results: In addition to the classical indications for hypothalamic amenorrhea, pulsatile GnRH treatment can also be used for drug-resistent hyperprolactinemia and some mixed forms of polycystic ovarian syndrome (PCOS). Current data demonstrate that pulsatile GnRH stimulation is one of the most effective forms of treatment in reproductive medicine, particularly in patients with hypothalamic amenorrhea and infertility. Discussion: In cases with clear indications, pulsatile GnRH should be the first choice treatment for ovarian stimulation. © 2016, Springer-Verlag Berlin Heidelberg.