Phase II Trial of Suramin in Patients with Metastatic Renal Cell Carcinoma

被引：0
作者：
Robert Dreicer
David C. Smith
Richard D. Williams
William A. See
机构：
[1] The University of Iowa,Department of Internal Medicine
[2] he University of Iowa Cancer Center,Department of Urology
[3] The University of Iowa,Department of Medicine
[4] The University of Michigan,undefined
来源：
Investigational New Drugs | 1999年 / 17卷
关键词：
carcinoma; renal cell; neoplasm metastasis; suramin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was conducted to assess the efficacy and toxicity of suramin administered using a fixed dose schedule in patients with advanced renal cell carcinoma. Fourteen eligible patients with advanced renal cell carcinoma were enrolled and treated on a fixed dose schedule of suramin administered over 12 weeks. Suramin was administered by intravenous infusions over 1 hour. None of the 13 evaluable patients demonstrated an objective response. Only 3 patients completed the 12-week therapy course, with the majority developing progressive disease on therapy. The fixed dosage schedule was well tolerated with minimal to moderate toxicity. Suramin in this fixed dose schedule is well tolerated but has no activity in advanced renal cell carcinoma.
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页码：183 / 186
页数：3
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