Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients

被引：0

作者：

Christelle Vauloup-Fellous

Sarah Maylin

Claire Périllaud-Dubois

Ségolène Brichler

Chakib Alloui

Emmanuel Gordien

Marie-Anne Rameix-Welti

Elyanne Gault

Frédérique Moreau

Slim Fourati

Dominique Challine

Jean-Michel Pawlotsky

Nadhira Houhou-Fidouh

Florence Damond

Vincent Mackiewicz

Charlotte Charpentier

Jean-François Méritet

Flore Rozenberg

Isabelle Podglajen

Stéphane Marot

Heloïse Petit

Sonia Burrel

Sepideh Akhavan

Marianne Leruez-Ville

Véronique Avettand-Fenoel

Jacques Fourgeaud

Tiffany Guilleminot

Elise Gardiennet

Stéphane Bonacorsi

Agnès Carol

Guislaine Carcelain

Juliette Villemonteix

Narjis Boukli

Joël Gozlan

Laurence Morand-Joubert

Jérome Legoff

Constance Delaugerre

Marie-Laure Chaix

Ana-Maria Roque-Afonso

Laurent Dortet

Thierry Naas

Jean-Baptiste Ronat

Samuel Lepape

Anne-Geneviève Marcelin

Diane Descamps

机构：

[1] University Paris Saclay,AP–HP, Hôpital Paul

[2] INSERM U1193,Brousse, Virologie, Department of Virology

[3] Université de Paris,Département des Agents Infectieux, Service de Virologie, Hôpital Saint

[4] INSERM UMR 944,Louis

[5] Laboratoire de Microbiologie Clinique,Laboratoire de Microbiologie

[6] Centre national de référence des hépatites B,INSERM

[7] C et Delta,Department of Virology, Hôpital Henri Mondor, “Viruses, Hepatology, Cancer” Research Unit

[8] Hôpital Avicenne,Laboratoire de Virologie, AP

[9] Université Paris Nord,HP, Hôpital Bichat

[10] Unité INSERM U955,Claude Bernard

[11] AP-HP. Université Paris Saclay,Service de Virologie

[12] Hôpital Ambroise Paré,Service de Virologie

[13] Université Paris-Saclay,Institut Pierre Louis d’Epidémiologie et de Santé Publique, IPLESP, AP

[14] Université Paris-Est,HP, Hôpital Pitié

[15] INSERM U955,Salpêtrière, Laboratoire de virologie

[16] Université de Paris,APHP Laboratoire de Microbiologie clinique, Hôpital Necker

[17] INSERM UMR 1137 IAME,Service de Microbiologie, Hôpital Robert

[18] Hôpital Cochin - APHP Centre - Université de Paris,Debré

[19] Hôpital Européen Georges Pompidou-APHP Centre - Université de Paris,Laboratoire d’immunologie, Hôpital Robert

[20] Sorbonne Université,Debré

[21] INSERM,Département de Virologie (Hôpital Saint

[22] Université de Paris,Antoine, Tenon, Trousseau)

[23] Faculté de Médecine,Service de Bactériologie

[24] INSERM U1016,Hygiène, Hôpital Bicêtre, Inserm U 1184; LabEx LERMIT

[25] CNRS UMR 8104,undefined

[26] Institut Cochin,undefined

[27] Université de Paris,undefined

[28] Université de Paris,undefined

[29] AP-HP Sorbonne Université,undefined

[30] INSERM-Sorbonne Universités UPMC,undefined

[31] Université Paris 06,undefined

[32] UMR-S 1136,undefined

[33] Institut Pierre Louis d’Epidémiologie et de Santé Publique (iPLESP),undefined

[34] Université Paris-Saclay,undefined

来源：

European Journal of Clinical Microbiology & Infectious Diseases | 2021年 / 40卷

关键词：

Serology; SARS-CoV-2; COVID-19;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We report evaluation of 30 assays’ (17 rapid tests (RDTs) and 13 automated/manual ELISA/CLIA assay (IAs)) clinical performances with 2594 sera collected from symptomatic patients with positive SARS-CoV-2 rRT-PCR on a respiratory sample, and 1996 pre-epidemic serum samples expected to be negative. Only 4 RDT and 3 IAs fitted both specificity (> 98%) and sensitivity (> 90%) criteria according to French recommendations. Serology may offer valuable information during COVID-19 pandemic, but inconsistent performances observed among the 30 commercial assays evaluated, which underlines the importance of independent evaluation before clinical implementation.

引用

页码：2235 / 2241

页数：6

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