Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting

被引:0
作者
Ramesh Pothuraju
Satyanarayana Rachagani
Wade M. Junker
Sanjib Chaudhary
Viswanathan Saraswathi
Sukhwinder Kaur
Surinder K. Batra
机构
[1] University of Nebraska Medical Center,Department of Biochemistry and Molecular Biology
[2] University of Nebraska Medical Center,Sanguine Diagnostics and Therapeutics
[3] University of Nebraska Medical Center,Department of Cellular & Integrative Physiology
[4] University of Nebraska Medical Center,Fred & Pamela Buffet Cancer Center
[5] University of Nebraska Medical Center,Eppley Institute for Research in Cancer and Allied Diseases
来源
Journal of Experimental & Clinical Cancer Research | / 37卷
关键词
Pancreatic cancer; Obesity; Insulin resistance; Diabetes; Adiponectin; Leptin; Gut microbiota; Inflammation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 888 条
[101]  
Hecht JR(2011)Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression Cancer Cell 19 441-122
[102]  
Gallinger S(2011)Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer Cancer Cell 19 456-2093
[103]  
Conroy T(2009)STATs in cancer inflammation and immunity: a leading role for STAT3 Nat Rev Cancer 9 798-7710
[104]  
Desseigne F(2001)Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation Cancer Res 61 6548-EE44
[105]  
Ychou M(2014)Pyruvate kinase M2 and cancer: an updated assessment FEBS Lett 588 2685-69
[106]  
Bouche O(2014)JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1alpha-mediated glucose metabolism Proc Natl Acad Sci U S A 111 279-E8E8
[107]  
Guimbaud R(2015)PKM2 contributes to cancer metabolism Cancer Lett 356 184-184
[108]  
Becouarn Y(2016)Pyruvate kinase m2 and lactate dehydrogenase a are overexpressed in pancreatic cancer and correlate with poor outcome PLoS One 11 e0151635-280
[109]  
Von Hoff DD(2014)The multifaceted regulation and functions of PKM2 in tumor progression Biochim Biophys Acta 1846 285-1140
[110]  
Ervin T(2011)Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation Nature 480 118-4718