An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

被引：0

作者：

Abdelmounaim Safer

Mustapha Rahmouni

François Carreaux

Ludovic Paquin

Olivier Lozach

Laurent Meijer

Jean Pierre Bazureau

机构：

[1] Université Ibn Khaldoun,Laboratoire de Synthèse et de Catalyse

[2] UMR CNRS 6226,Groupe Ingénierie Chimique et Molécules pour le Vivant (ICMV), Laboratoire Sciences Chimiques de Rennes

[3] CNRS,Protein Phosphorylation and Human Disease, Station Biologique de Roscoff

来源：

Chemical Papers | 2011年 / 65卷

关键词：

rhodanine; isatin; Knoevenagel condensation; solvent-free microwave;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.

引用

页码：332 / 337

页数：5

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