FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion

[1] DeNardo DG(2019)Macrophages as regulators of tumour immunity and immunotherapy Nat Rev Immunol 19 369-382

[2] Ruffell B(2018)Turn back the TIMe: targeting tumor infiltrating myeloid cells to revert cancer progression Front Immunol 9 1977-462

[3] Awad RM(2016)The role of myeloid cells in cancer therapies Nat Rev Cancer 16 447-674

[4] De Vlaeminck Y(2019)GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment Sci Immunol 4 8189-2453

[5] Maebe J(2016)Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards Nat Commun 7 12150-1247

[6] Goyvaerts C(2011)Hallmarks of cancer: the next generation Cell 144 646-110

[7] Breckpot K(2010)HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment J Exp Med 207 2439-703

[8] Engblom C(2015)Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies Cancer Immunol Res 3 1236-218

[9] Pfirschke C(2017)Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells Oncoimmunology 6 67-11319

[10] Pittet MJ(2017)Complex pharmacology of free fatty acid receptors Chem Rev 117 695-25489

[1] DeNardo DG(2019)Macrophages as regulators of tumour immunity and immunotherapy Nat Rev Immunol 19 369-382

[2] Ruffell B(2018)Turn back the TIMe: targeting tumor infiltrating myeloid cells to revert cancer progression Front Immunol 9 1977-462

[3] Awad RM(2016)The role of myeloid cells in cancer therapies Nat Rev Cancer 16 447-674

[4] De Vlaeminck Y(2019)GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment Sci Immunol 4 8189-2453

[5] Maebe J(2016)Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards Nat Commun 7 12150-1247

[6] Goyvaerts C(2011)Hallmarks of cancer: the next generation Cell 144 646-110

[7] Breckpot K(2010)HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment J Exp Med 207 2439-703

[8] Engblom C(2015)Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies Cancer Immunol Res 3 1236-218

[9] Pfirschke C(2017)Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells Oncoimmunology 6 67-11319

[10] Pittet MJ(2017)Complex pharmacology of free fatty acid receptors Chem Rev 117 695-25489