Advances in Continuous Active Pharmaceutical Ingredient (API) Manufacturing: Real-time Monitoring Using Multivariate Tools

[1] Poechlauer P(2012)Continuous processing in the manufacture of active pharmaceutical ingredients and finished dosage forms: an industry perspective Org Process Res Dev 16 1586-1590

[2] Manley J(2012)Using continuous processes to increase production Org Process Res Dev 16 852-869

[3] Broxterman R(2017)Regulatory perspectives on continuous pharmaceutical manufacturing: moving from theory to practice September 26–27, 2016, International symposium on the continuous manufacturing of pharmaceuticals J Pharm Sci 106 3199-3206

[4] Gregertsen B(2011)Economic analysis of integrated continuous and batch pharmaceutical manufacturing: a case study Ind Eng Chem Res 50 10083-10092

[5] Ridemark M(2014)Regulatory and quality considerations for continuous manufacturing J Pharm Sci 104 803-812

[6] Anderson NG(2015)Modernizing pharmaceutical manufacturing: from batch to continuous production J Pharm Innov 10 191-199

[7] Nasr MM(2015)Control systems engineering in continuous pharmaceutical manufacturing J Pharm Sci 104 832-839

[8] Krumme M(2017)Using PAT to accelerate the transition to continuous API manufacturing Anal Bioanal Chem 409 821-832

[9] Matsuda Y(2015)Industry perspectives on process analytical technology: tools and applications in API development Org Process Res Dev 19 63-83

[10] Trout BL(2017)Development of a commercial flow Barbier process for a pharmaceutical intermediate Org Process Res Dev 21 317-326

[1] Poechlauer P(2012)Continuous processing in the manufacture of active pharmaceutical ingredients and finished dosage forms: an industry perspective Org Process Res Dev 16 1586-1590

[2] Manley J(2012)Using continuous processes to increase production Org Process Res Dev 16 852-869

[3] Broxterman R(2017)Regulatory perspectives on continuous pharmaceutical manufacturing: moving from theory to practice September 26–27, 2016, International symposium on the continuous manufacturing of pharmaceuticals J Pharm Sci 106 3199-3206

[4] Gregertsen B(2011)Economic analysis of integrated continuous and batch pharmaceutical manufacturing: a case study Ind Eng Chem Res 50 10083-10092

[5] Ridemark M(2014)Regulatory and quality considerations for continuous manufacturing J Pharm Sci 104 803-812

[6] Anderson NG(2015)Modernizing pharmaceutical manufacturing: from batch to continuous production J Pharm Innov 10 191-199

[7] Nasr MM(2015)Control systems engineering in continuous pharmaceutical manufacturing J Pharm Sci 104 832-839

[8] Krumme M(2017)Using PAT to accelerate the transition to continuous API manufacturing Anal Bioanal Chem 409 821-832

[9] Matsuda Y(2015)Industry perspectives on process analytical technology: tools and applications in API development Org Process Res Dev 19 63-83

[10] Trout BL(2017)Development of a commercial flow Barbier process for a pharmaceutical intermediate Org Process Res Dev 21 317-326