Human photopic response to circulating glucose

被引：16

作者：

Dawson W.W. ^{[1
]}

Hazariwala K. ^{[1
]}

Karges S. ^{[1
]}

机构：

[1] Department of Ophthalmology, University of Florida, Gainesville, Fl

来源：

Documenta Ophthalmologica | 2000年 / 101卷 / 2期

关键词：

Diabetes; ERG; Glucose; Human; Photopic; Retina;

D O I：

10.1023/A:1026569701949

中图分类号：

学科分类号：

摘要：

Circulating glucose was manipulated in young human volunteers with clinically normal vision. Fasting achieved a concentration range of 45-91 mg/dl. And sugar loading produced a range of 79-108 mg/dl. Glucose increased in all subjects. A nonparametric ANOVA provided a p=0.0005 for the significance of the concentration differences between group glucose concentrations under the two conditions in the sample. Each volunteer participated in each condition of the repeated-measures design. Clinical tests were completed before electroretinograms were recorded under photopic and scotopic adaptation conditions. Measures were made from 12 eyes. Only photopic adaptation conditions with maximal stimuli produced significant results. Inter-individual differences were robust and constrained to reduced implicit times for b-wave peaks and 30 Hz flicker implicit times. Under the elevated glucose conditions. Other variables showed very strong trends. These results confirm and extend other human indications of photopic retinal sensitivity to variations within the normal range of circulating glucose concentrations.

引用

页码：155 / 163

页数：8

共 22 条

[1]

Simonsen S.E., The value of the oscillatory potential in selecting juvenile diabetics at risk of developing proliferative retinopathy, Acta Ophthalmol, 58, pp. 865-878, (1980)

[2]

Algvere P., Gjotterberg M., The diagnostic value of the oscillatory potentials of the ERG and fluorescein angiography in diabetic proliferative retinopathy, Ophthalmologica, 168, pp. 97-108, (1974)

[3]

Hardy K.J., Lipton J., Scase M., Foster D.H., Scarpello J., Detention of colour vision abnormalities in uncomplicated type 1 diabetic patients with angiographically normal retina, Brit J. Ophthalmol, 76, pp. 461-464, (1992)

[4]

Greenstein V., Sarter B., Hood D., Nobel K., Carr R., Hue discrimination and S cone pathway sensitivity in early diabetic retinopathy, Invest Ophthamol Vis Sci., 31, pp. 1008-1014, (1990)

[5]

Hirsch-Hoffman C., Niemeyer G., Changes in plasma glucose level affect rod, but not cone- ERG in the anesthetized cat, Clin. Vision Sci, 8, pp. 489-501, (1993)

[6]

Niemeyer G., Ouoe S., Macaluso C., Glucose concentration affects the rod-ERG and optic nerve response in the perfused cat eye, Invest Ophthalmol Vis Sci, 31, (1990)

[7]

Maculoso C., Ouoe S., Niemeyer G., Changes in glucose level affect rod function more than cone function in the isolated, perfused cat eye, Invest Opthalmol Vis Sci, 33, pp. 2798-2808, (1992)

[8]

Dawson W., Trick G., Litzkow C., Improved electrode for electroretinography, Invest Ophthalmol, 18, pp. 988-991, (1979)

[9]

Siegel S., Nonparametric Statistics, (1956)

[10]

Bush R., Sieving P., The Proximal retinal component in the primate photopic ERG a-wave, Invest Ophthalmol Vis Sci., 35, pp. 635-645, (1994)

← 1 2 3 →