The effects of desflurane on human platelet aggregation in vitro

被引：0

作者：

Türkan H. ^{[1
]}

Beyan C. ^{[2
,5
]}

Karabiyik L. ^{[3
]}

Güner D. ^{[4
]}

Kaptan K. ^{[2
]}

机构：

[1] Clinic of Anaesthesiology, Department of Emergency Medicine, Gulhane Military Medical Academy, Ankara

[2] Department of Haematology, Gulhane Military Medical Academy, Ankara

[3] Department of Anaesthesiology, Gazi University, Faculty of Medicine, Ankara

[4] Department of Anaesthesiology, Ministry of Health, Ankara Train. and Research Hospital, Ankara

[5] Gulhane Military Medical Academy, Department of Haematology, 06010 Etlik, Ankara

来源：

International Journal of Hematology | 2004年 / 80卷 / 1期

关键词：

Anesthetics; Desflurane; Platelet aggregation; Platelet function;

D O I：

10.1532/IJH97.E0309

中图分类号：

学科分类号：

摘要：

In view of the possible antiplatelet effects of general anesthetics, we investigated the in vitro effects of desflurane, a new inhalation agent, on platelet aggregation. For 15 patients who underwent elective operations, blood was sampled with desflurane induction before and after anesthesia but prior to surgery so that platelet aggregation in the drawn blood could be tested before desflurane anesthesia and again after exposure to the anesthetic. Platelet aggregation was measured with a whole-blood aggregometer. Adenosine diphosphate (ADP), collagen, and ristocetin were used as aggregating agents. Our results showed that aggregation in response to ADP, collagen, or ristocetin was not inhibited in patients who received desflurane anesthesia. This study with an in vitro model showed that desflurane had no influence on platelets in clinically relevant doses. ©2004 The Japanese Society of Hematology.

引用

页码：91 / 93

页数：2

共 19 条

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