Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations

被引：0
作者：
H. K. Stulzer
P. O. Rodrigues
T. M. Cardoso
J. S. R. Matos
M. A. S. Silva
机构：
[1] Universidade Federal de Santa Catarina,Department of Science Pharmacy
[2] Universidade de São Paulo,Department of Elementar Chemistry, Chemistry Institute
来源：
Journal of Thermal Analysis and Calorimetry | 2008年 / 91卷
关键词：
captopril; compatibility; FTIR; thermoanalytical techniques; X-ray powder diffraction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Captopril (CAP) was the first commercially available angiotensine-converting enzyme (ACE) inhibitor. In the anti-hypertensive therapy is considered the selected drug has to be therapeutically effective together with reduced toxicity. CAP is an antihypertensive drug currently being administered in tablet form. In order to investigate the possible interactions between CAP and excipients in tablets formulations, differential scanning calorimetry (DSC) and thermogravimetric (TG) analysis completed by X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR) were used for compatibility studies. A possible drug-excipient interaction was observed with magnesium stearate by DSC technique.
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页码：323 / 328
页数：5
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