New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol

被引：30

作者：

Fan H. ^{[1
]}

Kim S.M. ^{[1
]}

Cho Y.J. ^{[1
]}

Eo M.Y. ^{[1
]}

Lee S.K. ^{[2
]}

Woo K.M. ^{[3
]}

机构：

[1] Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 62-1 Changgyeonggungno, Jongno-gu, Seoul

[2] Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung

[3] Department of Dental Pharmacology and Therapeutics, Dental Research Institute, School of Dentistry, Seoul National University, Seoul

来源：

Biomaterials Research | / 18卷 / 1期

关键词：

Osteoradionecrosis (ORN); Pentoxifylline; Radiotherapy; Tocopherol;

D O I：

10.1186/2055-7124-18-13

中图分类号：

学科分类号：

摘要：

Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced. In this review article, we will discuss the definition and classifications of osteoradionecrosis, its etiology and pathophysiology, previous treatment options, oral and maxillofacial complications of radiotherapy, basic information on pentoxifylline and tocopherol, recent reports of pentoxifylline and tocopherol combined therapy, and, finally, ORN-induced animal models and future approaches. © 2014 Fan et al.

引用

共 48 条

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