Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation

被引：0

作者：

T. S. Tracy

C. Marra

S. A. Wrighton

F. J. Gonzalez

K. R. Korzekwa

机构：

[1] Department of Basic Pharmaceutical Sciences,

[2] School of Pharmacy,undefined

[3] West Virginia University,undefined

[4] HSN P.O. Box 9530,undefined

[5] Morgantown,undefined

[6] WV 26506,undefined

[7] USA Tel. +1-304-293-1474; fax +1-304-293-5483; e-mail tstracy@wvnvm.wvnet.edu,undefined

[8] Department of Drug Disposition,undefined

[9] Eli Lilly and Co.,undefined

[10] Indianapolis,undefined

[11] Indiana,undefined

[12] USA,undefined

[13] National Cancer Institute,undefined

[14] National Institutes of Health,undefined

[15] Bethesda,undefined

[16] Maryland,undefined

[17] USA,undefined

[18] Center for Clinical Pharmacology,undefined

[19] University of Pittsburgh,undefined

[20] Pittsburgh,undefined

[21] Pennsylvania,undefined

[22] USA,undefined

来源：

European Journal of Clinical Pharmacology | 1997年 / 52卷

关键词：

Key words Naproxen; Cytochrome P450; human liver microsomes; vaccinia virus; cDNA expression;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objective: A series of studies was undertaken to determine the cytochrome P450 isoform(s) involved in naproxen demethylation and whether this included the same isoforms reported to be involved in the metabolism of other NSAIDs.

引用

页码：293 / 298

页数：5

共 50 条

[31] Identification of cytochrome p450 isoforms involved in citalopram N-demethylation by human liver microsomes
Kobayashi, K
Chiba, K
Yagi, T
Shimada, N
Taniguchi, T
Horie, T
Tani, M
Yamamoto, T
Ishizaki, T
Kuroiwa, Y
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1997, 280 (02): : 927 - 933
[32] Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
Zhang, Hai-Feng
Li, Zhi-Hui
Liu, Jia-Yu
Liu, Ting-Ting
Wang, Ping
Fang, Yan
Zhou, Jun
Cui, Ming-Zhu
Gao, Na
Tian, Xin
Gao, Jie
Wen, Qiang
Jia, Lin-Jing
Qiao, Hai-Ling
DRUG METABOLISM AND DISPOSITION, 2016, 44 (08) : 1193 - 1200
[33] Effect of Crocetin on Cytochrome P450 Isoforms In Vitro
Zhang, Jie
Zhang, Bin
Sun, Bin
LATIN AMERICAN JOURNAL OF PHARMACY, 2021, 40 (09): : 2159 - 2163
[34] Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
Reisky, Lukas
Buechsenschuetz, Hanna C.
Engel, Jennifer
Song, Tao
Schweder, Thomas
Hehemann, Jan-Hendrik
Bornscheuer, Uwe T.
NATURE CHEMICAL BIOLOGY, 2018, 14 (04) : 342 - +
[35] Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen
Miners, JO
Coulter, S
Tukey, RH
Veronese, ME
Birkett, DJ
BIOCHEMICAL PHARMACOLOGY, 1996, 51 (08) : 1003 - 1008
[36] Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases
Robb, Craig S.
Reisky, Lukas
Bornscheuer, Uwe T.
Hehemann, Jan-Hendrik
BIOCHEMICAL JOURNAL, 2018, 475 : 3875 - 3886
[37] Which P450: Predicting which cytochrome P450 isoforms are involved in the metabolism of a xenobiotic
Hunt, Peter
Tyzak, Jonathan
Segall, Matthew
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[38] Which P450: predicting which cytochrome p450 isoforms are involved in the metabolism of a xenobiotic
Tyzack, Jon D.
Foster, Nicholas W.
Hunt, Peter
Segall, Matthew D.
DRUG METABOLISM REVIEWS, 2016, 48 : 45 - 45
[39] REGIOSELECTIVE O-DEMETHYLATION OF SCOPARONE - DIFFERENTIATION BETWEEN RAT-LIVER CYTOCHROME-P-450 ISOZYMES
MULLERENOCH, D
BUTTGEN, E
NONNENMACHER, A
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1985, 40 (9-10): : 682 - 684
[40] Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
Busse, D
Cosme, J
Beaune, P
Kroemer, HK
Eichelbaum, M
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1995, 353 (01) : 116 - 121

← 1 2 3 4 5 →