Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation

被引：0

作者：

T. S. Tracy

C. Marra

S. A. Wrighton

F. J. Gonzalez

K. R. Korzekwa

机构：

[1] Department of Basic Pharmaceutical Sciences,

[2] School of Pharmacy,undefined

[3] West Virginia University,undefined

[4] HSN P.O. Box 9530,undefined

[5] Morgantown,undefined

[6] WV 26506,undefined

[7] USA Tel. +1-304-293-1474; fax +1-304-293-5483; e-mail tstracy@wvnvm.wvnet.edu,undefined

[8] Department of Drug Disposition,undefined

[9] Eli Lilly and Co.,undefined

[10] Indianapolis,undefined

[11] Indiana,undefined

[12] USA,undefined

[13] National Cancer Institute,undefined

[14] National Institutes of Health,undefined

[15] Bethesda,undefined

[16] Maryland,undefined

[17] USA,undefined

[18] Center for Clinical Pharmacology,undefined

[19] University of Pittsburgh,undefined

[20] Pittsburgh,undefined

[21] Pennsylvania,undefined

[22] USA,undefined

来源：

European Journal of Clinical Pharmacology | 1997年 / 52卷

关键词：

Key words Naproxen; Cytochrome P450; human liver microsomes; vaccinia virus; cDNA expression;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objective: A series of studies was undertaken to determine the cytochrome P450 isoform(s) involved in naproxen demethylation and whether this included the same isoforms reported to be involved in the metabolism of other NSAIDs.

引用

页码：293 / 298

页数：5

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