Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

[1] Blot SI(2014)The effect of pathophysiology on pharmacokinetics in the critically ill patient–concepts appraised by the example of antimicrobial agents Adv Drug Deliv Rev 77 3-11

[2] Pea F(2015)Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization Curr Opin Pharmacol 24 1-6

[3] Lipman J(2013)Plasma pharmacokinetics of antimicrobial agents in critically ill patients Curr Clin Pharmacol 8 5-12

[4] Sime FB(2012)What’s behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance Int J Antimicrob Agents 39 455-457

[5] Udy AA(2015)Glycocalyx and sepsis-induced alterations in vascular permeability Crit Care 19 26-1368

[6] Roberts JA(2000)Microalbuminuria as an early index of impairment of glomerular permeability in postoperative septic patients Intensive Care Med 26 1364-767

[7] Pea F(2011)Population pharmacokinetics of ceftriaxone in critically ill septic patients: a reappraisal Br J Clin Pharmacol 72 758-694

[8] Udy AA(2001)Clinical use of ceftriaxone: a pharmacokinetic–pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding Clin Pharmacokinet 40 685-474

[9] Roberts JA(1999)Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients Chest 115 462-533

[10] De Waele JJ(2015)Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients Br J Clin Pharmacol 80 525-1556

[1] Blot SI(2014)The effect of pathophysiology on pharmacokinetics in the critically ill patient–concepts appraised by the example of antimicrobial agents Adv Drug Deliv Rev 77 3-11

[2] Pea F(2015)Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization Curr Opin Pharmacol 24 1-6

[3] Lipman J(2013)Plasma pharmacokinetics of antimicrobial agents in critically ill patients Curr Clin Pharmacol 8 5-12

[4] Sime FB(2012)What’s behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance Int J Antimicrob Agents 39 455-457

[5] Udy AA(2015)Glycocalyx and sepsis-induced alterations in vascular permeability Crit Care 19 26-1368

[6] Roberts JA(2000)Microalbuminuria as an early index of impairment of glomerular permeability in postoperative septic patients Intensive Care Med 26 1364-767

[7] Pea F(2011)Population pharmacokinetics of ceftriaxone in critically ill septic patients: a reappraisal Br J Clin Pharmacol 72 758-694

[8] Udy AA(2001)Clinical use of ceftriaxone: a pharmacokinetic–pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding Clin Pharmacokinet 40 685-474

[9] Roberts JA(1999)Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients Chest 115 462-533

[10] De Waele JJ(2015)Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients Br J Clin Pharmacol 80 525-1556