Asymmetric Ir-catalyzed hydrogenation of 1,3-dihydro-2H-1,5-benzodiazepin-2-ones using phosphoramidites

被引：0
作者：
M. V. Sokolovskaya
S. E. Lyubimov
I. S. Mikhel
K. P. Birin
V. A. Davankov
机构：
[1] Russian Academy of Sciences,A. N. Nesmeyanov Institute of Organoelement Compounds
[2] Russian Academy of Sciences,A. N. Frumkin Institute of Physical Chemistry and Electrochemistry
来源：
Russian Chemical Bulletin | 2018年 / 67卷
关键词：
asymmetric hydrogenation; phosphoramidites; mixed ligands; 1,5-benzodiazepin-2-ones;
D O I：
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学科分类号：
摘要：
A series of phosphoramidite ligands was tested in the asymmetric hydrogenation of 4-arylsubstituted 1,3-dihydro-2H-benzodiazepine-2-ones and up to 52% ee was achieved. The effects of various factors (solvents, hydrogen pressure, and addition of phosphine ligands) on the hydrogenation were studied.
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页码：260 / 264
页数：4
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