Ameliorative effects of Vaccaria segetalis extract on osteopenia in ovariectomized rats

被引：0
作者：
Chun-Ching Shih
Cheng-Hsiu Lin
Wei-Li Lin
机构：
[1] Central Taiwan University of Science and Technology,Institute of Pharmaceutical Science and Technology, College of Health Science
[2] Department of Health,Department of Internal Medicine, Fong
[3] National Chung-Hsing University,Yuan Hospital
来源：
Journal of Natural Medicines | 2009年 / 63卷
关键词：
Ovariectomy; Osteopenia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The purpose of this study was to determine the ameliorative effects of a crude extract of Vaccaria segetalis (Neck.) Garcke (Caryophyllaceae) (VSE) on osteopenia in ovariectomized (OVX) rats over 12 weeks. Rats were divided into the sham and OVX groups. The OVX rats were allowed to lose bone for 6 weeks. At 6 weeks post-OVX, the OVX rats were divided into four groups treated with water, 17β-estradiol (30 μg/kg, daily subcutaneous injection), or VSE (0.5 or 1.0 g/kg, daily, orally) for 6 weeks. In OVX rats, the increases of serum total cholesterol were significantly decreased by VSE or 17β-estradiol treatment. There were decreases in bone density and calcium content, including the left femur and the fourth lumbar vertebra, when compared with the sham control rats. Treatment with 17β-estradiol or VSE ameliorated these changes induced by OVX. In addition, ovariectomy increased urinary deoxypyridinoline (DPD) amounts (P < 0.001). The increases were suppressed by 17β-estradiol and 0.5 or 1.0 g/kg VSE (P < 0.01, P < 0.05, P < 0.01, respectively). Our results demonstrated that VSE ameliorates ovariectomy-induced osteopenia by inhibition of bone resorption.
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页码：386 / 392
页数：6
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