The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

被引:0
作者
Carlos A. Castaneda
Hernán Cortes-Funes
Henry L. Gomez
Eva M. Ciruelos
机构
[1] Instituto Nacional Enfermedades Neoplásicas,
[2] Hospital Universitario 12 de Octubre,undefined
来源
Cancer and Metastasis Reviews | 2010年 / 29卷
关键词
PIK3CA; PTEN; p110α; Akt; mTOR; breast cancer;
D O I
暂无
中图分类号
学科分类号
摘要
The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway mediates the effects of a variety of extracellular signals in a number of cellular processes including cell growth, proliferation, and survival. The alteration of integrants of this pathway through mutation of its coding genes increases the activation status of the signaling and can thus lead to cellular transformation. The frequent dysregulation of the PI3K/Akt pathway in breast cancer (BC) and the mediation of this pathway in different processes characteristically implicated in tumorigenesis have attracted the interest of this pathway in BC; however, a more comprehensive understanding of the signaling intricacies is necessary to develop clinical applications of the modulation of this pathway in this pathology. We review a series of experiments examining the contribution of alteration of integrants of this signaling network to human BC and we make an update of the information about the effect of the modulation of this pathway in this cancer.
引用
收藏
页码:751 / 759
页数:8
相关论文
共 123 条
[1]  
Dillon RL(2007)The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer Oncogene 26 1338-1345
[2]  
White DE(2009)PTEN and the PI3-kinase pathway in cancer Annual Review of Patholology 4 127-150
[3]  
Muller WJ(2008)The type 1 insulin-like growth factor receptor pathway Clinical Cancer Research 14 6364-6370
[4]  
Chalhoub N(2001)Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation Journal of Biological Chemistry 276 17686-17692
[5]  
Baker SJ(2009)Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression Cancer Research 69 5057-5064
[6]  
Chitnis MM(2005)The ERK/MAPK pathway, as a target for the treatment of neuropathic pain Expert Opinion on Therapeutic Targets 9 699-713
[7]  
Dayanir V(2009)A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell Current Opinion in Genetics and Development 19 51-59
[8]  
Dillon RL(2008)Taming the PI3K team to hold inflammation and cancer at bay Pharmacology and Therapeutics 118 192-205
[9]  
Ma W(2009)Epithelial-mesenchymal transitions in development and disease Cell 139 871-890
[10]  
Quirion R(2009)EMT, the cytoskeleton, and cancer cell invasion Cancer Metastasis Reviews 28 15-33