Pulmonary Hypertension Due to Left Ventricular Cardiomyopathy: Is it the Result or Cause of Disease Progression?

被引：6

作者：

Adusumalli S. ^{[1
]}

Mazurek J.A. ^{[1
,2
]}

机构：

[1] Department of Medicine, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA

[2] Department of Medicine, Advanced Heart Failure/Transplantation and Pulmonary Hypertension Programs, Hospital of the University of Pennsylvania, Philadelphia, PA

来源：

Current Heart Failure Reports | 2017年 / 14卷 / 6期

关键词：

Cardiomyopathy; Heart failure; Left heart disease; Pulmonary hypertension; Valvular heart disease; WHO group 2;

D O I：

10.1007/s11897-017-0368-2

中图分类号：

学科分类号：

摘要：

Purpose of Review: The purpose of this review is to define pulmonary hypertension in the setting of left heart disease (PH-LHD), discuss its epidemiology and pathophysiology, and highlight the cause and effect relationship it has with disease progression in the setting of cardiomyopathy. Recent Findings: Both pulmonary hypertension (PH) and heart failure are becoming increasingly common. As such, PH-LHD is now the most common form of PH. The pathophysiology of the condition relates to backward transmission of elevated left ventricular filling pressures into the pulmonary circulation and, ultimately, right ventricular (RV) strain/dysfunction. It is evident that these pathophysiologic processes are both the effect and cause of left heart disease progression. Summary: In this review, we describe the complex relationship between disease progression in left ventricular cardiomyopathy and PH-LHD. Clinicians and researchers should take note of the importance of PH-LHD and RV dysfunction to appropriately risk stratify patients and develop therapies for the condition. © 2017, Springer Science+Business Media, LLC.

引用

页码：507 / 513

页数：6

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