Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier

被引：0
作者：
Nan Hu
Xiaoli Shi
Qiang Zhang
Wentao Liu
Yuting Zhu
Yuqing Wang
Yi Hou
Yinglu Ji
Yupeng Cao
Qian Zeng
Zhuo Ao
Quanmei Sun
Xiaohan Zhou
Xiaochun Wu
Dong Han
机构：
[1] National Center for Nanoscience and Technology,CAS Center for Excellence in Nanoscience
[2] University of Chinese Academy of Sciences,School of Future Technology
[3] Chengde Medical University,Department of Traditional Chinese Medicine
[4] Chinese Academy of Sciences,Institute of Chemistry
来源：
Nano Research | 2019年 / 12卷
关键词：
nanoparticles; interstitial stream; mass transportation; blood-brain barrier; magnetic resonance imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nowadays, nanoparticles (NPs) are considered to be ideal tools for bioimaging and drug delivery. Although increasing research has focused on NP biodistribution, transportation in the interstitial architecture has been neglected. The entire body is connected by the interstitial architecture, which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system. In this study, we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats (intervaginal space injection (ISI)) were delivered to the brain without crossing the blood-brain barrier. Furthermore, NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging. The results demonstrated that, after ISI, the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain. This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution.
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页码：2760 / 2765
页数：5
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