The Impact of Hepatitis A Virus Infection on Hepatitis C Virus Infection: A Competitive Exclusion Hypothesis

被引：0
作者：
Marcos Amaku
Francisco Antonio Bezerra Coutinho
Eleazar Chaib
Eduardo Massad
机构：
[1] University of São Paulo,School of Veterinary Medicine
[2] University of São Paulo,School of Medicine
[3] LIM 01-HCFMUSP,undefined
[4] London School of Hygiene and Tropical Medicine,undefined
来源：
Bulletin of Mathematical Biology | 2013年 / 75卷
关键词：
Hepatitis A; Hepatitis C; Competitive exclusion principle; Mathematical models;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.
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页码：82 / 93
页数：11
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